Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and …

In this study, we determined the feasibility of using serum miRNAs to predict the extent of structural and functional CNS impairments associated with alcohol use disorders. The subjects recruited for this study were selected to reflect the same average age and an equal number of males and females in each group (Table 1). Compared to our previous study that explored the use of mRNA profiles from peripheral blood leukocytes [3], the current study focused on a younger group of individuals, allowing exploration of potentially more sensitive biomarkers of early CNS alterations. Such early detection could promote development of therapeutic and preventative interventions that might halt or potentially reverse the CNS effects. On average our AUD subjects had been drinking an average of 12 years, starting around age 18. They drank alcohol an…


Link to Full Article: Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and …

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