Adversity in childhood and depression: linked through SIRT1

Citation: Translational Psychiatry (2015) 5, e629; doi:10.1038/tp.2015.125Published online 1 September 2015L Lo Iacono1,5, F Visco-Comandini2,5, A Valzania1, M T Viscomi1, M Coviello3, A Giampà3, L Roscini4, E Bisicchia1, A Siracusano3, A Troisi3, S Puglisi-Allegra1,4 and V Carola1 Top of page Introduction Exposure to traumatic events and receiving little parental care in early life are risk factors for mood disorders in adulthood.1 Childhood adversity is associated with significant differences in the clinical picture of depressive illnesses, including earlier onset, a more sustained course of disease, more severe symptoms and worse treatment outcomes.2, 3, 4 On the basis of these findings, Teicher and Samson5 hypothesized that depressed patients who have experienced childhood maltreatment constitute a distinct clinical ‘ecophenotype’ (per Teicher and Samson’s terminology) that is likely characterized by specific etiological pathways.6, 7, 8 Consistent with this hypothesis, recent studies have shown that depression and inflammation cluster…


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